Compound
The drug contains 10 or 15 mg of sibutramine as an active substance, as well as microcrystalline cellulose (Cellulose microcrystalline), lactose (Lactose), colloidal silicon dioxide (Silicium dioxide colloidal), magnesium stearate (Magnesii stearas).
The composition of the Goldline 10 mg capsule body includes: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate), dyes (sunset yellow and quinoline yellow).
To make the body of Goldline 15 mg capsules, the following are used: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate).
Composition of the capsule cap: gelatin (Gelatine), titanium dioxide (Titanium dioxide), sodium lauryl sulfate (Sodium lauryl sulfate), dyes (diamond blue and acid fuchsin D&C33).
Indications and contraindications
Goldline Light can be prescribed to a patient if he diligently trains and eats exclusively dietary foods, but this has little effect on weight. If after three months of such activities a person cannot lose more than 5 kg, then a drug is prescribed as a booster.
Unlike its more serious counterparts, Goldline Light has a modest list of strict contraindications, all of which are listed in the instructions. It cannot be used:
- When breastfeeding.
- During pregnancy.
- For diseases of the kidneys, liver, heart and gastrointestinal tract.
- In case of intolerance to substances in the composition of the drug.
Pharmacodynamics and pharmacokinetics
Goldline is a centrally acting agent for the treatment of obesity.
Its active substance sibutramine is a prodrug that exhibits its pharmacological properties in vivo due to primary and secondary amines - products of drug metabolism, which are characterized by the ability to inhibit the reuptake of monoamines (mainly serotonin and norepinephrine ).
The use of the medicine allows you to increase the feeling of satiety, reduce the need for food, and also increase thermal production. These effects are achieved by increasing the content of neurotransmitters in synapses and, consequently, increasing the activity of central serotonin (type 5-HT) and adrenergic receptors.
Sibutramine also has the ability to act on brown adipose tissue through indirect activation of β3-adrenergic receptors.
Weight loss, in turn, is accompanied by an increase in serum concentrations of high-density lipoproteins and a decrease in the concentrations of low-density lipoproteins, total cholesterol, uric acid and triglycerides.
Neither sibutramine nor its metabolic products:
- do not inhibit the enzyme monoamine oxidase (MAO);
- do not affect the release of monoamines ;
- do not have an affinity for a sufficiently large number of neurotransmitter receptors (including serotonin types 5HT1-, 5HT1A-, 5HT1B-, 5HT2A-, 5HT2C-; adrenergic beta 1, 2 and 3, as well as alpha 1 and 2; dopamine D1 and D2; benzodiazepine, muscarinic, NMDAR, histamine H1-).
After taking p/os, sibutramine is absorbed from the digestive tract by at least 77%. During the first passage through the liver, the substance is metabolized under the influence of the P4503A4 isoenzyme to mono- and didesmethylsibutramine , which are its active metabolites.
The substance is quickly distributed throughout the tissues. The protein binding rate for sibutramine is 97%, for its metabolites - 94%.
T1/2 of sibutramine - 1.1 hours, metabolites - 14 and 16 hours (for mono- and didesmethylsibutramine, respectively). After hydroxylation and conjugation, active metabolites are biotransformed into inactive ones, which are eliminated mainly by the kidneys.
Contraindications
The drug has a number of contraindications, including:
- hypersensitivity to its components;
- the patient has organic causes of obesity;
- mental illness;
- congenital heart defects;
- bulimia nervosa or anorexia nervosa ;
- Tourette's disease;
- decompensated heart failure;
- arrhythmia and tachycardia ;
- obliterating atherosclerosis of the arteries of the lower extremities;
- cardiac ischemia;
- cerebrovascular diseases (including, but not limited to, transient cerebral circulatory disorders and strokes );
- arterial hypertension (when blood pressure is more than 145/90 mm Hg);
- severe or liver dysfunction
- pheochromocytoma;
- hyperthyroidism;
- prostate adenoma , which is accompanied by the appearance of residual urine;
- angle-closure glaucoma;
- taken in combination with MAO inhibitors or other drugs that affect the central nervous system (and also if less than 14 days have passed since their discontinuation);
- simultaneous use of other anorexigenic drugs;
- established alcohol, drug or drug addiction;
- age over 65 years and under 18 years.
It is recommended to prescribe Goldline with caution to patients with mild to moderately severe disorders of liver and/or kidney function, neurological disorders (including mental retardation and increased seizure activity, including a history), motor or verbal tics (including a history), insufficiency chronic blood circulation, coronary artery diseases (including a history), cholelithiasis , arrhythmia ; controlled arterial hypertension , as well as if hypertension is noted in the anamnesis.
Goldline
Use during pregnancy and breastfeeding
Since to date there is not a sufficiently convincing amount of research regarding the safety of the effects of sibutramine on the fetus, this drug should not be used during pregnancy.
Goldline should not be taken while breastfeeding.
Women of childbearing age should use contraception while taking Goldline.
Use for liver dysfunction
The drug should be prescribed with caution for mild to moderate liver dysfunction.
Use for renal impairment
The drug should be prescribed with caution in cases of mild to moderate renal dysfunction.
Use in children
Contraindication: age under 18 years.
Use in elderly patients
Contraindication: age over 65 years.
special instructions
Goldline should be used only in cases where all non-drug measures for weight loss are ineffective, if the weight loss over 3 months is less than 5 kg.
Treatment with Goldline should be carried out as part of complex weight loss therapy under the supervision of a physician with practical experience in the treatment of obesity. Complex therapy includes both changing diet and lifestyle, as well as increasing physical activity. An important component of therapy is the creation of prerequisites for permanent changes in eating habits and lifestyle, which are necessary to maintain the achieved weight loss even after drug therapy is discontinued. As part of Goldline therapy, patients need to change their lifestyle and habits in such a way as to ensure that the achieved weight loss is maintained after completion of treatment. Patients should be clear that failure to comply with these requirements will lead to repeated weight gain and repeated visits to their doctor.
In patients taking Goldline, it is necessary to measure blood pressure and heart rate. During the first 2 months of treatment, these parameters should be monitored every 2 weeks and then monthly. In patients with arterial hypertension whose blood pressure level is above 145/90 mm Hg during antihypertensive therapy. Art., this control should be carried out especially carefully and, if necessary, at shorter intervals. In patients whose blood pressure exceeded 145/90 mm Hg twice during repeated measurements. Art., treatment with Goldline should be suspended.
The simultaneous administration of drugs that increase the QT interval requires special attention. These drugs include histamine H1 receptor blockers (astemizole, terfenadine), antiarrhythmic drugs that increase the QT interval (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol), cisapride, pimozide, sertindole and tricyclic antidepressants. This also applies to conditions that can lead to an increase in the QT interval, such as hypokalemia and hypomagnesemia.
The interval between taking MAO inhibitors and Goldline should be at least 2 weeks.
Although no connection has been established between taking Goldline and the development of primary pulmonary hypertension, however, given the well-known risk of drugs in this group, with regular medical monitoring it is necessary to pay special attention to symptoms such as progressive dyspnea, chest pain and swelling in the legs.
If you miss a dose of Goldline, you should not take a double dose of the drug at the next dose; it is recommended to continue taking the drug according to the prescribed regimen.
The duration of taking Goldline should not exceed 2 years.
Impact on the ability to drive vehicles and operate machinery
Taking Goldline may limit the ability to drive vehicles and operate machinery.
Side effects
The most common side effects associated with the use of the drug Goldline occur in the first weeks of treatment (they are usually observed during the first month). Over time, their severity and frequency of occurrence decrease.
In general, side effects associated with taking the drug do not pose a threat to health and are reversible.
The most common adverse events (occurring in at least every 10 patients):
- insomnia;
- loss of appetite;
- feeling of dry mouth;
- constipation.
Sometimes (occur with a frequency of 1-10%) the following may appear:
- headache;
- increased anxiety;
- dizziness;
- paresthesia;
- vasodilator effect (including hyperemia of the skin);
- moderate increase in heart rate (on average 3-7 beats per minute);
- tachycardia;
- increased blood pressure (at rest, they increase by an average of 1-3 mm Hg);
- heartbeat;
- exacerbation of hemorrhoids ;
- nausea and change in taste;
- increased sweating.
At the initial stages of treatment with Goldline, a more significant change in blood pressure and pulse rate is possible (usually such phenomena are observed in the first 4-8 weeks of taking the drug).
In isolated cases, such clinically significant side effects were recorded as: skin itching, development of flu-like syndrome , dysmenorrhea , back and abdominal pain, edema, paradoxical increase in appetite, drowsiness, bleeding, convulsions, increased thirst, runny nose, depression, mood lability, irritability , nervousness, anxiety, acute interstitial nephritis , rheumatic purpura , transient increase in the activity of liver enzymes in the blood , thrombocytopenia .
One patient with schizoaffective psychosis , which most likely existed before the start of drug treatment, developed acute psychosis .
The body's response to stopping Goldline, which manifests itself in the form of headaches and increased appetite, rarely develops.
evidence that withdrawal symptoms , withdrawal symptoms , or mood disturbances may occur after stopping treatment.
GOLDLINE PLUS caps. 10+158.5 mg No. 30
Contraindications
- established hypersensitivity to sibutramine or other components of the drug;
- presence of organic causes of obesity (for example, hypothyroidism);
- serious eating disorders - anorexia nervosa or bulimia nervosa;
- mental illness;
— Gilles de la Tourette syndrome (generalized tics);
- simultaneous use of MAO inhibitors (for example, phentermine, fenfluramine, dexfenfluramine, ethylamphetamine, ephedrine) or use within 2 weeks before taking Goldline PLUS and 2 weeks after the end of its use of other drugs acting on the central nervous system, inhibiting the return serotonin uptake (eg, antidepressants, antipsychotics); sleeping pills containing tryptophan, as well as other centrally acting drugs for weight loss or for the treatment of mental disorders;
- cardiovascular diseases (history or current): coronary heart disease (myocardial infarction (MI), angina pectoris); chronic heart failure in the stage of decompensation, occlusive diseases of peripheral arteries, tachycardia, arrhythmia, cerebrovascular diseases (stroke, transient cerebrovascular accidents);
- uncontrolled arterial hypertension (blood pressure (BP) above 145/90 mmHg);
- angle-closure glaucoma;
- thyrotoxicosis;
- severe dysfunction of the liver and/or kidneys;
- benign prostatic hyperplasia;
- pheochromocytoma;
— established pharmacological, drug or alcohol dependence;
- pregnancy and breastfeeding;
- age under 18 and over 65 years.
The drug should be prescribed with caution in the following conditions: a history of arrhythmias, chronic circulatory failure, coronary artery diseases (including a history), except for coronary heart disease (MI, angina); glaucoma, except for angle-closure glaucoma, cholelithiasis, arterial hypertension (controlled and with a history), neurological disorders, including mental retardation and seizures (including a history), epilepsy, impaired liver and/or kidney function of mild to moderate severity , a history of motor and verbal tics, a tendency to bleeding, bleeding disorders, taking drugs that affect hemostasis or platelet function.
Goldline tablets, instructions for use
How to take Goldline capsules
The starting dose of the drug is 10 mg/day. If the expected effect is not observed when using it (in situations where body weight decreases by less than 2 kg during a month of treatment), as well as if the drug is well tolerated, the dose is increased to 15 mg/day.
If there is no effect even when using a higher dosage (weight decreases by less than 2 kg per month), treatment with sibutramine is stopped.
In patients who do not adequately respond to the prescribed treatment, that is, within three months their weight decreases by less than five percent of the original, the duration of use of Goldline should not exceed 3 months.
The maximum duration of treatment is two years. This is due to the lack of reliable data on the safety and effectiveness of using sibutramine over a longer period of time.
You should not continue taking the drug if, after achieving weight loss during further treatment, the patient again gains three (or more) kilograms.
It is considered advisable to supplement therapy with physical activity and diet. Training should be carried out under the supervision of a specialist who has sufficient practical experience in treating people suffering from obesity.
Instructions for Goldline Light
Goldline Light is a drug produced by the pharmaceutical company Izvarino Pharma LLC.
The official website of the tablets states that this product is not a drug and is used by overweight people who actively use physical activity to lose weight, as a dietary supplement.
The daily dose of the drug contains 48 mg of lipoic acid and 360 mg of l-carnitine (vitamin BT).
In combination with moderate physical activity and a low-calorie diet, weight loss with the use of the product increases by 22% with regular use for six months. In this case, the concentration of α-lipoic acid should be at least 1% of the weight of the total amount of food eaten.
With moderate intensity physical activity, fat burning increases by 36-55%.
In addition, α-lipoic acid is a good antioxidant, which, due to its ability to dissolve in both non-polar and polar solvents, exhibits its properties both in cells and in the extracellular space.
cATP-dependent protein kinase which influences human eating behavior , resulting in increased energy expenditure and decreased food consumption.
The effect of using the drug is dose-dependent.
In accordance with the instructions, take 1 or 2 Goldline Light capsules approximately 15-20 minutes before the start of training and then within 60-90 minutes after it ends.
Lipoic acid is a medication prescribed for cirrhosis or fatty liver , hepatitis A , and chronic hepatitis . Lipoic acid is not available without a prescription because it often causes the following side effects:
- severe allergic reactions (this may be itching, urticaria or systemic allergic reactions);
- dyspepsia.
At the same time, in the instructions supplied with the Goldline Light dietary supplement, the manufacturer does not warn about the possibility of developing such side effects.
You should also remember that taking capsules should not be combined with taking any multivitamin complexes, drugs for the treatment of anemia and other drugs that contain calcium, potassium, iron or magnesium ions.
How to take Goldline Light correctly
It is recommended to start the course with the smallest dose – 10 mg. If after 10 days the result is insignificant or not at all, then if you feel well, the dose of Goldline Light is increased by another 5 mg.
Directions for use and dosage
You should take the capsules with meals, with plenty of water, twice a day. Usually 2 capsules are prescribed per dose, but in some cases one Goldline Light is enough.
Course duration
According to one group of experts, you can take capsules for 3 weeks, then take a break for at least a week, and if necessary, repeat the three-week course.
Other experts believe that you can take Goldline Light for up to 2 years without a break, however, they recommend quitting if after three months you have not lost more than 5% of your total body weight.
In both cases, it is important to constantly monitor the pressure: at 140/90, if this is not your normal pressure, stop taking Goldline Light capsules.
Dosage regimens
First, talk to your doctor to determine the duration of the course in your case. If you stop at three weeks, you will most likely be prescribed two capsules per dose. In the second case - one at a time. Other features:
- There is a lot of glucose in the blood of a well-fed person, so muscles use it as energy, and fats will only be reached half an hour after the start of physical activity. Therefore, it is advisable to eat one and a half to two hours before the start of training.
- Half an hour before starting physical exercise, take Goldline Light.
- An hour and a half after finishing the workout, take the product again, because at this time fat burning continues, and the effect of the product at this time increases by 55%.
How long does it take for it to start working?
The results of losing weight confirm that each body perceives the drug individually. Although, if you take something average from the reviews, you can say offhand that in 10 days you lose about 3 extra kilos.
What you can and cannot combine with
I was surprised that neither the manufacturer nor the majority of nutritionists (not all!) prohibit the simultaneous use of other dietary supplements and medications for weight loss. The only thing distributors of the drug ask you to remember when combining it with others are side effects. When used together, the risk of causing side effects is higher, and this may affect your overall well-being.
As for food, there are no strict restrictions, although it is advisable not to indulge in high-calorie and fatty foods. What you should definitely avoid is alcohol: it actually blocks the work of Goldline Light, stimulating a brutal appetite, which means that all the work done turns out to be in vain.
Overdose
To date, there is not enough data on sibutramine . An increase in the severity of adverse reactions is considered the most likely.
If a suspected overdose of Goldline occurs, you should notify your doctor.
There are no specific antidotes or special treatment. It is recommended to ensure the patient can breathe freely and keep the condition of the cardiovascular system under control. Further therapy is symptomatic.
Timely intake of activated carbon and gastric lavage procedure can reduce the absorption of the drug in the intestinal tract.
Patients who have high blood pressure may be prescribed β-blockers .
The effectiveness of hemodialysis or forced diuresis has not been established.
Interaction
The simultaneous use of sibutramine with inhibitors of microsomal oxidation (including the CYP3A4 isoenzyme) increases the plasma concentration of its metabolites, heart rate and provokes a clinically insignificant increase in the QT interval.
The metabolism of sibutramine is accelerated when used in combination with phenytoin , Dexamethasone , Carbamazepine , Rifampicin , Phenobarbital and macrolide antibiotics .
Serious interactions are possible in the case of simultaneous administration of several drugs that increase the concentration of serotonin in the blood.
In rare cases, serotonin syndrome develops when sibutramine is used in combination with:
- selective serotonin reuptake inhibitors, which are used to treat depression and anxiety disorders;
- certain antimigraine drugs (for example, dihydroergotamine or sumatriptan );
- antitussives ( dextromethorphan );
- opioid analgesics ( Fentanyl , pentazocine , pethidine ).
Sibutramine does not affect the action of oral contraceptives.
With simultaneous use of sibutramine with ephedrine , pseudoephedrine , phenylpropanolamine and combination drugs containing these substances, the risk of increased blood pressure and heart rate increases.
The substance does not enhance the negative effects of ethanol, however, drinking alcohol during treatment with Goldline reduces the effectiveness of dietary measures.
Effect of diet pills Goldline
Goldline effectively regulates appetite and increases the secretion of serotonin, which is a chemical compound that affects brain cells. What can be said about the consequences of using goldline? Firstly, taking this drug leads to mental disturbances and heart problems.
In addition, this drug is not used in America, Australia and Canada. This is due to the fact that, according to doctors, the consequences of taking Goldline are much more dangerous than its effectiveness. It is also worth considering reviews from people who have used this product. Based on them, we can conclude that using the drug is not worth it - headaches, dry mouth, pressure surges and obsessive mental states accompany the use of this drug.
The use of goldline is characterized by certain contraindications. We are talking about increased eye pressure, bulimia and anorexia due to nervousness, all kinds of mental pathologies, increased sensitivity to the drug, as well as diseases of the cardiovascular system and kidneys.
It should be borne in mind that the influence of “sibutramine” drugs for weight loss, which includes Goldline, is not limited to the saturation center in the brain. It also affects other parts of the central nervous system. This can be complicated by insomnia, overexcitement, headaches, increased heart rate and increased blood pressure.
special instructions
Goldline diet pills are prescribed only in cases where all other measures aimed at weight loss are ineffective. Treatment should be carried out under the supervision of a specialist who has sufficient experience in weight correction for obesity as part of complex treatment (including physical activity, review of diet, habitual lifestyle, diet).
The period of taking Goldline at a dose of 15 mg should be limited in time.
In the first 8 weeks of treatment, heart rate and blood pressure should be monitored every 2 weeks. After this time, monitoring is carried out once a month.
For patients with arterial hypertension (when the pressure is at the level of 145/90 mm Hg), blood pressure and heart rate are recommended to be monitored more often and more carefully. If the pressure rises above the specified values 2 times, treatment with Goldline is stopped.
The appearance of chest pain, swelling of the legs, and progressive dyspnea may indicate the development of pulmonary hypertension (such conditions require consultation with a doctor).
Women of childbearing age should use effective contraception throughout the entire course of use.
Sibutramine has the ability to reduce salivation, cause a feeling of discomfort in the oral cavity, provoke the development of caries and periodontal , thrush .
During the treatment period, you should refrain from performing work that could potentially threaten your health and life, as well as from driving a car.
Goldline
Goldline should be used only in cases where all non-drug measures for weight loss are ineffective, if the weight loss over 3 months is less than 5 kg.
Treatment with Goldline should be carried out as part of complex weight loss therapy under the supervision of a physician with practical experience in the treatment of obesity. Complex therapy includes both changing diet and lifestyle, as well as increasing physical activity. An important component of therapy is the creation of prerequisites for permanent changes in eating habits and lifestyle, which are necessary to maintain the achieved weight loss even after drug therapy is discontinued. As part of Goldline therapy, patients need to change their lifestyle and habits in such a way as to ensure that the achieved weight loss is maintained after completion of treatment. Patients should be clear that failure to comply with these requirements will lead to repeated weight gain and repeated visits to their doctor.
In patients taking Goldline, it is necessary to measure blood pressure and heart rate. During the first 2 months of treatment, these parameters should be monitored every 2 weeks and then monthly. In patients with arterial hypertension whose blood pressure level is above 145/90 mm Hg during antihypertensive therapy. Art., this control should be carried out especially carefully and, if necessary, at shorter intervals. In patients whose blood pressure exceeded 145/90 mm Hg twice during repeated measurements. Art., treatment with Goldline should be suspended.
The simultaneous administration of drugs that increase the QT interval requires special attention. These drugs include histamine H1 receptor blockers (astemizole, terfenadine), antiarrhythmic drugs that increase the QT interval (amiodarone, quinidine, flecainide, mexiletine, propafenone, sotalol), cisapride, pimozide, sertindole and tricyclic antidepressants. This also applies to conditions that can lead to an increase in the QT interval, such as hypokalemia and hypomagnesemia.
The interval between taking MAO inhibitors and Goldline should be at least 2 weeks.
Although no connection has been established between taking Goldline and the development of primary pulmonary hypertension, however, given the well-known risk of drugs in this group, with regular medical monitoring it is necessary to pay special attention to symptoms such as progressive dyspnea, chest pain and swelling in the legs.
If you miss a dose of Goldline, you should not take a double dose of the drug at the next dose; it is recommended to continue taking the drug according to the prescribed regimen.
The duration of taking Goldline should not exceed 2 years.
Impact on the ability to drive vehicles and operate machinery
Taking Goldline may limit the ability to drive vehicles and operate machinery.
Analogs
Level 4 ATC code matches:
Sibutramine
Meridia
Lindaxa
Analogues by mechanism of action:
- Reduxin
- Fepranon
- Goldline-Light
Structural analogues (generics):
- Lindaxa
- Meridia
- Slimia
During pregnancy
The category of action on the developing fetus in accordance with the FDA classification is C. This means that animal studies have established a negative effect of the drug on the fetus, but strictly controlled studies of the use of the drug during pregnancy in humans have not been conducted.
It has also not been established whether sibutramine or its metabolites can pass into breast milk.
This excludes the possibility of using the drug by pregnant women and during breastfeeding.
Reviews about Goldline
Comments and reviews from those losing weight about Goldline 15 mg and 10 mg are quite contradictory. Some note the high effectiveness of the product (some women claim that by taking capsules for weight loss, they lost 7-8 kg in 3-8 weeks), while others say that taking the drug did not give them the desired result, but only provoked a lot of unpleasant symptoms ( pressure surges, headaches, dizziness, weakness, etc.).
In addition, in some reviews of Goldline diet pills, women complain that after stopping taking the capsules, their appetite noticeably increased, and the lost pounds returned almost immediately.
Doctors in reviews of Goldline tablets write that sibutramine is a potent substance that can be sold in pharmacies only with a prescription. It has quite a lot of contraindications and often provokes side effects.
Thus, they recommend taking the drug for weight loss only after consultation with a specialist and a thorough assessment of your health.
The use of the drug is advisable for obesity (that is, when the patient’s BMI is more than 30 kg/sq. m, in exceptional cases - at least 27 kg/sq. m) and only in the absence of endocrine diseases, heart and vascular diseases, mental disorders and certain individual indicators that can be identified by the attending physician.
Only the attending physician can select the optimal dosage regimen (15 or 10 mg) and determine how long the treatment will be.
Often among reviews of Goldline there are also reviews of Goldline Light. Unlike Goldline, it is not a medicine, but a dietary supplement. As noted by women and girls who have taken the drug, the effect of its use is noticeable only if a low-calorie diet is followed and a sufficient level of physical activity is provided.
Simply taking capsules will not help you lose weight.
Feedback from hosts
Natalya, 36: “I managed to lose 6 kg in a month. I was quite satisfied with the result, although I can’t say for sure whether it’s from Goldline Light or from regular training.”
Masha, 24: “I took another drug before, I was happy. Goldline Light was offered as an alternative when one day my product was not available at the pharmacy. As for me, the result is zero, the only advantage over my favorite product is the price.”
Zhenya, 28: “The heartburn is terrible, constipation is terrible, insomnia, and as a result - constant aggressiveness... Was such torment worth it? Not in my case: minus 1.5 kg in 30 days.”
Olga, 32: “I’m happy with the effect: I started losing weight slowly but surely, when I signed up for fitness, things went even faster. There were no particular side effects, except that in the first days I had a slight headache and a slight increase in blood pressure. And I was thirsty all the time, but for me this is more an advantage than a disadvantage - before that, I always forgot to replenish my water balance. It’s a little expensive, of course, but I’ve been drinking for three months now, and I’ve already lost 11 kg.”
Before and after results
Judging by the photo, the product really helped someone noticeably:
What doctors and studies say
According to the results of a clinical study in 2014, the effect of Goldline Light is certainly high. The volunteers participating in the experiment were divided into two groups, in one, all participants took 4 capsules of Goldline Light per day. Both groups ate so that the total calorie intake did not exceed 2200 kcal per day; in addition, people took walks every day and trained in the gym.
Participants in the group that took Goldline Light confirmed its effectiveness: the weight loss was almost twice as great as that of the team that lost weight without it. However, for those who are now inspired by the results of others, let me remind you: healthy people were chosen to participate in the experiment, and they struggled with excess weight under the supervision of top-class nutritionists.
By the way, I note that doctors speak about Goldline Light with some caution: they say that it seems to be practically safe, but at the same time, there are no completely harmless drugs. All doctors confirm that side effects are observed in most cases. However, with proper treatment, including the necessary training, which is best combined with a proper diet, you can control the dynamics and stop the process in a timely manner if Goldline Light capsules begin to act negatively or not work at all.
Goldline price, where to buy
Price of diet pills in Russian pharmacies:
- from 1400 rub. per capsule 10 mg No. 30;
- from 3100 rub. per capsule 10 mg No. 90;
- from 2000 rub. per capsule 15 mg No. 30;
- from 3700 rub. per capsule 15 mg No. 60;
- from 5300 rub. for capsules 15 mg No. 90.
The tablets are available with a prescription. If desired, they can be ordered online without a prescription. In large cities (for example, Krasnoyarsk, Moscow or Yekaterinburg), online pharmacies offer to buy Goldline with home delivery.
- Online pharmacies in RussiaRussia
ZdravCity
- Goldline Plus capsules 15mg+153.5mg 30 pcs. Izvarino Pharma LLC
RUB 2,146 order - Goldline Plus capsules 15mg+153.5mg 90 pcs. Izvarino Pharma LLC
RUR 5,305 order
- Goldline Plus capsules 10mg+158.5mg 30 pcs. Izvarino Pharma LLC
RUB 1,429 order
- Goldline Plus capsules 10 mg + 158.5 mg 90 pcs. Izvarino Pharma LLC
RUR 3,136 order
- Goldline Plus capsules 10mg+158.5mg 60 pcs. Izvarino Pharma LLC
RUB 2,322 order