In this article we will look at whether Duphaston makes you fat. This pharmaceutical product belongs to the category of hormonal medications containing the hormone progesterone. This medicine is used in gynecological clinical practice for the treatment of various pathologies that are accompanied by hormonal disorders, for example, insufficient concentration of progesterone in the patient’s blood, menstrual irregularities, and normalization of pregnancy.
Many women are interested in whether Duphaston makes them gain weight. The answer will be presented below.
Composition and release form
This medication is manufactured in the form of tablets for oral administration, white, round, biconvex in shape with beveled borders. There is a separation line on one side of the tablets. The main active element of the drug is dydrogesterone, the content of which in 1 tablet is 10 mg. In addition, it contains some excipients, the list of which includes:
- hypromellose;
- colloidal silicon dioxide;
- lactose monohydrate;
- corn starch;
- titanium dioxide;
- magnesium stearate;
- polyethylene glycol.
The medicine is packaged in blisters of 20 and 28 tablets. The cardboard box contains one blister and an annotation on the use of the drug.
Do Duphaston make you fat? The instructions will tell us about this.
Is it possible to recover from duphaston during pregnancy?
Hello everyone! I often read the revelations of girls in this community, but I never got around to registering... and now it’s “boiled”... everything is in order... my husband and I have been together for 16 years... we separated a couple of times, but not for long, and now we have finally decided that we are without each other we don’t have a lifelong friend...we’ve been expecting children in our family for about 12 years, but...all my life I’ve been diagnosed with ovarian dysfunction (or polycystic ovary syndrome, it’s the same thing), I don’t get a cycle without duphaston. We’ve been to a bunch of doctors, tests and other things so far We really got to the pros... we came to her in February 2021. A bunch of tests, HSG + RDV (done personally by our doctor, who was seen by us), 3 courses of physiotherapy and in December the long-awaited IVF, transfer and on the 4th day the long-awaited // on the test ...happiness knew no bounds...then I got very sick (I work at a school, apparently, and got sick when I went in for an hour), I suffered from a fever for 2 days out of fear that they would take me to the hospital and do something to the baby...when the temperature rose to 38.5 called an ambulance... spent a week in the infectious diseases hospital and ran away (I recovered, but they didn’t really treat me there)... froze at 6 weeks... to say that life ended there is an understatement... even our doctor was in shock... cried into her pillow for a week and decided that it was time to pull myself together and move on, towards our children... fortunately, 5 more of our children were waiting for us in cryo-freezing... our doctor, the professor, still didn’t want to enter into the cryo-protocol - I didn’t like my endometrium, but at the same time I didn’t prescribe any medications, only physical therapy (I went through it a total of 4 times in a year and a half)... I took Palpel almost once every 2 months (my husband is doing well and they even wanted to take him as a donor)... after cleaning the frozen one, they did a full analysis of the baby( the doctors called him something else, but I can’t dare to call him anything else)... he was a completely healthy boy and our first doctor concluded that the disease was due to my illness... and I got tired of waiting... went to another fertility specialist in another clinic (our first doctor-professor spoke well of both this clinic and this reproductologist) and with the new reproductologist we entered into a cryo-protocol, and before that we passed genetic tests and judging by them, the disease was due to antibodies... they sent to a hemotologist, she said that you can take a risk and try to do a transfer, but it’s not a fact that pregnancy will occur due to antibodies, and she prescribed plasmapheresis in case of pregnancy (I didn’t consider another option)… they did a cryo-transfer and a flight… even without implantation… After crying for another week, I got ready and went and did plasmapheresis (5 procedures), and now I don’t know what to do next... in some confusion... or go back to the doctor, professor first, and wait for the ideal endometrium (but given dysfunction and a frozen pregnancy, this is unrealistic ) or go to a second reproductive specialist and try further (there are 4 more babies in cryo-freezing) or look for a third reproductive specialist? If anyone has a good reproductive specialist, I would be grateful for contacts or at least full name... Girls, what should I do? What do you think? Maybe it’s worth going with a second reproductive specialist to try the transfer after plasmapheresis and if it doesn’t work, then return to the first one who has already had a positive result? Please advise what you would do...
Pharmacological properties
The main active element - dydrogesterone - in its chemical formula and clinical actions is similar to its own (endogenous) progesterone, synthesized in the female body. Therefore, when taken orally, this hormone has similar biological effects. Due to the fact that dydrogesterone is not a derivative of testosterone (male sex hormones), it does not have androgenic (testosterone effect), estrogenic (clinical estrogen effect), glucocorticoid (glucocorticoid effect) effects. It also does not affect the processes of carbohydrate metabolism in the body and does not change hemostasis (blood clotting).
After taking the drug Duphaston, body temperature does not change. Dydrogesterone helps stabilize the blood lipid profile (the ratio and level of essential fats, including cholesterol). The active element of Duphaston tablets has a direct effect on the condition of the endometrium (the mucous membrane of the uterus) and prevents the development of its hypertrophy (pathological increase in size).
After oral administration of the drug, the active substance is absorbed from the intestinal lumen into the blood. It is distributed in tissues and undergoes a metabolic process in the liver with the formation of breakdown products, which are excreted from the body through the kidneys in the urine. The half-life of the substance (half the dose of the drug) is 18 hours.
Women want to get a doctor's answer to the question of whether Duphaston makes them fat.
Indications and contraindications for Duphaston
The drug is actively used in gynecological practice for progesterone deficiency, including the use of Duphaston for the treatment of endometriosis. In addition, it is indicated for infertility, menstrual dysfunction, amenorrhea, dysfunctional uterine bleeding, and hormone replacement therapy during menopause.
Contraindications for the use of the drug are intolerance to its components and allergic reactions. Duphaston should also be used with caution during the lactation period, as it passes into breast milk.
In any case, medications should be prescribed by a doctor after a thorough examination. Self-administration of medications can harm the body and cause adverse reactions. You can get detailed information about the drug and undergo a full examination at the IVF Center clinic in Kursk.
Indications for use
The main indication for the use of a pharmacological drug is progesterone deficiency (decreased concentration of endogenous progesterone in the body) in the following pathological conditions:
- infertility, which is caused by insufficient functionality of the luteal phase of the menstrual cycle, the functioning of the corpus luteum (luteal insufficiency);
- endometriosis - the development of ectopic foci in endometrial cells outside the uterus;
- the threat of spontaneous miscarriage during pregnancy due to insufficient concentration of endogenous progesterone in the blood;
- premenstrual syndrome, which is accompanied by severe functional disorders in the woman’s body and pain;
- dysmenorrhea (irregularity of the menstrual cycle during reproductive age);
- lack of menstruation of a secondary nature (amenorrhea), caused by various pathologies of the reproductive system;
- uterine bleeding when functional disorders occur in the organs of the reproductive system.
In addition, this pharmacological drug is used in hormone replacement therapy in cases where it is necessary to neutralize the increased effect of estrogens on the endometrial layer of the uterus during the period of induced (after surgery) or natural postmenopause.
Are Duphaston and obesity related? Let's figure it out.
Dosage and method of administration
The drug "Duphaston" is prescribed to be taken orally, without chewing, with water. Dosages and regimen of medication depend on the type of pathology:
- For endometriosis – 1 tablet 2 times a day from the 5th to the 25th day of the cycle.
- If there is a threat of miscarriage - 40 mg once, then 10 mg every 8 hours.
- Habitual miscarriage - 1 tablet in 2 doses per day until the 20th week of gestation, after which the dosage of the drug must be gradually reduced.
- Infertility due to insufficiency of the corpus luteum - 1 tablet 1 time per day from the 14th to the 25th day of the cycle.
- Premenstrual syndrome, amenorrhea – 1 tablet 2 times a day from the 11th to the 25th day.
- Dysmenorrhea – 1 tablet 2 times a day from the 5th to the 25th day of the cycle.
- Dysfunctional bleeding from the genital tract - to stop for 5-7 days, the pharmacological agent "Duphaston" is taken in a dosage of 10 mg 2 times a day, in order to prevent relapses - 10 mg 2 times a day from the 11th to the 25th day of the cycle .
During the period of hormone replacement treatment (including amenorrhea therapy), this pharmacological drug is taken simultaneously with estrogens, 1 tablet 1 time per day from the 14th day. With constant use of estrogen, the medication is taken according to the same regimen.
How to lose weight after Duphaston
First of all, you will have to adjust your diet, applying the principles mentioned above. For a while, it will be useful to remove refined sugar, baked goods and baked goods made from premium flour, potatoes, white rice and pasta from your diet.
Watch the amount of salt in your food - it can cause swelling, which will add pounds to you in the mirror and on the scale.
It is better to eat in small portions, about 5 times a day - this speeds up your metabolism and prevents you from gaining weight. Eat a protein-rich dinner with some vegetables. It’s better to start the day with complex carbohydrates - they will give you a boost of energy and a lasting feeling of fullness.
Choose a physical activity that is pleasant and adequate to your condition, exercise regularly - losing weight will not take long.
Side effects
Whether Duphaston makes you fat is not an idle question.
Taking the medication can lead to the development of certain pathological reactions of the body, which include:
- Liver, digestive and hepatobiliary system - pain in the abdomen, impaired functionality of the gallbladder and liver, which manifests itself in the form of general weakness, a feeling of heaviness in the area of the right hypochondrium, slight jaundice.
- Nervous system – headaches that are severely paroxysmal in nature, reminiscent of a migraine.
- Red bone marrow and blood - hemolytic anemia, which is characterized by excessive destruction of red blood cells.
- Reproductive system - development of uterine bleeding, which is stopped by increasing the dosage of the drug Duphaston, increased sensitivity of the mammary glands.
- Allergic phenomena are characteristic skin changes in the form of rash, itching. Rarely, general sensitivity reactions such as angioedema and anaphylactic shock may occur.
If side effects occur, it is recommended to stop taking the medication or adjust its dosage.
Do Duphaston make you fat? Expert's answer
Many women believe that weight gain is directly related to taking hormonal medications. However, this is not always the case. Experts say that today only hormonal drugs are produced that have low dosages of hormones, so they are not capable of causing the development of obesity in women during the treatment period.
So, do you get better from Duphaston or not?
If a woman begins to gain significant weight while taking the drug, this indicates, first of all, that her appetite is increasing, and this is considered normal when hormonal levels are normalized. Gynecologists and nutritionists recommend that such patients adhere to the correct diet and dietary rules.
Reviews of women about the fullness of Duphaston are presented below.
How can it not get better?
If the patient has been prescribed a long or short course of taking Duphaston, it is necessary to select workouts that will provide the required dose of load. Reasons why you need to exercise:
- along with balancing the synthesis of hormones, metabolic processes in the body are also normalized;
- the positive effect of sports on strengthening blood vessels will prevent possible side effects of the drug;
- the functioning of the liver and kidneys improves, as a result of which the remaining drug is eliminated from the body faster;
- the effectiveness of the hormonal drug will be consolidated even after the cessation of replacement therapy.
During pregnancy, it is recommended to attend yoga classes or swimming in the pool. The most important areas that require development during training are the lower back, neck and spine.
Reasons for the increase in volumes
The basis of the diet is individual for everyone, some prefer fatty foods, and some prefer spicy foods. And each of them provides benefits for the body, but in moderation.
While following a diet, you cannot completely exclude fats from the menu, because... they promote the absorption of many vitamins and microelements from incoming food.
If before taking Duphaston, a woman had problems with metabolism, in order not to gain weight, along with hormonal therapy, she must contact a nutritionist who can prescribe the correct nutrition program.
You may also need psychological help, because there are often cases of legitimate avoidance of sexual intercourse against the background of a painful menstrual cycle, obesity or infertility.
Special Recommendations
Before starting treatment, it is important to read the instructions. In some cases, diffuse uterine bleeding may develop. If bleeding does not stop after increasing the dose of medication, further gynecological examination should be performed to determine the cause.
When combined treatment with products containing estrogens, their side effects and contraindications should be taken into account.
Before starting hormonal replacement treatment using the pharmacological drug Duphaston, a comprehensive examination is carried out to determine adverse reactions, features of the functionality of the organs of the reproductive and urinary system and other pathological processes, including medical history.
According to indications, it is possible to use the medication during pregnancy under the supervision of a specialist.
If necessary, during lactation the child should be switched to artificial milk formula.
In the case of progesterone-dependent tumors (benign or malignant), it is important to conduct clinical studies of their reaction to the intake of the main component of this drug into the body.
It is not recommended to prescribe the drug to patients with congenital, hereditary lactase deficiency.
The tablets do not affect the speed of mental and motor reactions, as well as concentration.
Duphaston®
Before starting treatment with Duphaston® for abnormal uterine bleeding, it is necessary to find out the cause of the bleeding. With prolonged use of the drug, periodic examinations by a gynecologist are recommended, the frequency of which is determined individually, but at least once every six months.
In the first months of treatment for abnormal uterine bleeding, “breakthrough” bleeding or “spotting” may occur. If “breakthrough” bleeding or “spotting” spotting occurs after a certain period of taking the drug or continues after a course of treatment, you should contact your doctor and carry out appropriate additional examination, and, if necessary, do an endometrial biopsy to exclude neoplasms in the endometrium.
If dydrogesterone is prescribed in combination with estrogens for the purpose of hormone replacement therapy (HRT), you should carefully read the contraindications and special instructions associated with the use of estrogens.
HRT should be prescribed to treat menopausal symptoms that adversely affect the patient's quality of life. The benefit/risk ratio of HRT should be assessed annually. Therapy should be continued until the potential benefit outweighs the potential risk.
There is limited data on the risks associated with HRT for the treatment of premature menopause. Due to the low absolute risk in younger women, the benefit/risk ratio for them may be more favorable compared with that for older women.
Medical examination
Before starting the use of a combination of dydrogesterone and estrogen (for HRT), a complete individual and family history should be collected. An objective examination (including examination of the pelvic organs and mammary glands) should be performed to identify possible contraindications and conditions requiring precautions.
During treatment, it is recommended to periodically monitor individual tolerance to HRT. The patient should be informed about what changes in the mammary glands she should report to the doctor. (See breast cancer). Studies including mammography should be carried out in accordance with generally accepted screening, taking into account individual characteristics and the clinical picture.
Hyperplasia and endometrial cancer
In women with an intact uterus, the risk of endometrial hyperplasia and cancer increases with long-term estrogen monotherapy.
Cyclic use of progestogens, including dydrogesterone (at least 12 days of a 28-day cycle) or the use of a sequential combined HRT regimen in women with a preserved uterus may prevent the increased risk of endometrial hyperplasia and cancer with estrogen monotherapy.
Mammary cancer
Available evidence suggests that the risk of breast cancer is increased in women treated with estrogen-progestogen HRT, and possibly also with estrogen monotherapy. The level of risk depends on the duration of HRT. The results of the epidemiological study and the WHI (Women's Health Initiative) study confirm an increased risk of developing breast cancer in women taking drugs containing a combination of estrogen and progesterone as part of HRT. The risk increases after about three years of use, but returns to the mean within a few (usually five) years after the end of therapy.
While taking drugs for HRT, especially with combined therapy with estrogens and progestogens, an increase in the density of breast tissue during mammography may be observed, which can make it difficult to diagnose breast cancer.
Ovarian cancer
Ovarian cancer is much less common than breast cancer.
Epidemiological data from a large meta-analysis suggest a small increase in risk for women receiving HRT as estrogen monotherapy or combination therapy with estrogens and progestogens. An increase in this risk becomes apparent with treatment duration of more than five years, and after its cessation the risk gradually decreases over time. Findings from a number of other studies, including the WHI, indicate that combined HRT is associated with a similar or slightly lower risk of ovarian cancer.
Venous thromboembolism
HRT is associated with a 1.3- to 3-fold increase in the risk of venous thromboembolism (VTE), i.e. deep vein thrombosis or pulmonary embolism. The likelihood is highest in the first year of HRT than in subsequent years. Patients with established thrombophilia have an increased risk of developing venous thromboembolism, and HRT may increase the risk. For this reason, HRT is contraindicated in such patients.
Risk factors for venous thromboembolism include estrogen use, advanced age, major surgery, prolonged immobilization, obesity (BMI > 30 kg/m2), pregnancy, the postpartum period, systemic lupus erythematosus and cancer. There is no clear data on the possible role of varicose veins in the development of venous thromboembolism.
If long-term immobilization after surgery is necessary, you should stop taking HRT medications 4-6 weeks before surgery, resuming the drug is possible after the woman has fully recovered her motor activity.
Women with no history of VTE, but with a family history of thrombosis at a young age in close relatives, may be offered screening after detailed counseling about the possible limitations and disadvantages of therapy (screening reveals only some of the hereditary defects of the hemostatic system) .
If thrombophilia associated with thrombosis is detected in family members or if there is a severe defect (for example, deficiency of antithrombin III, protein C, protein S, or a combination of defects), HRT is contraindicated.
If the patient is taking anticoagulants, the benefits/risks of HRT must be carefully assessed. Until a thorough assessment of the factors for the possible development of thromboembolism or the initiation of anticoagulant therapy is completed, HRT drugs are not prescribed. If thrombosis develops after initiation of therapy, HRT should be discontinued.
You should immediately consult a doctor if any of the symptoms indicating a possible thromboembolism appear (painful swelling of the lower extremities, sudden chest pain, shortness of breath, blurred vision).
Coronary heart disease (CHD)
Data obtained from randomized controlled trials indicate a lack of protective effect against the development of myocardial infarction in women with and without coronary artery disease receiving HRT in the form of combination therapy with estrogens and progestogens or estrogen monotherapy.
The relative risk of developing coronary heart disease increases slightly during combined HRT. The absolute risk of developing CHD depends on age. The incidence of CHD associated with HRT use in healthy women near natural menopause is very low, but the risk increases with age.
Ischemic stroke
Combination therapy with estrogens and progestogens or estrogens alone is associated with a 1.5-fold increase in the risk of ischemic stroke. The relative risk does not change with age and does not depend on the time of menopause. However, the incidence of stroke varies with age, and the overall risk of stroke in women taking HRT will increase with age.
Excipients
The drug contains lactose monohydrate.
Patients with rare hereditary diseases such as galactose intolerance, lactase deficiency or glucose-galactose malabsorption syndrome should not take the drug.
Consequences of taking
After treatment with this medication, women's menstrual cycle stabilizes, the threat of miscarriage during pregnancy disappears, the condition during premenstrual syndrome stabilizes, and pathological uterine bleeding during menopause stops.
We reviewed the instructions for Duphaston. Does it make you fat? According to women, yes.
How does the drug affect a woman’s health?
To answer the question of whether Duphaston makes you fat, you need to carefully study the instructions for the drug and reviews of women who have taken this medicine.
The treating specialist prescribes hormone therapy in exceptional cases when there are all indications for this.
Indications for prescribing the drug:
- endometriosis;
- infertility caused by dysfunction of the ovaries;
- premenstrual syndrome;
- PMS violation;
- infertility caused by uterine endometritis;
- infertility of endocrine etiology;
- uterine bleeding;
- dysmenorrhea and other menstrual cycle disorders;
- threat of spontaneous abortion due to progesterone deficiency.
With the help of Duphaston, the functioning of the reproductive system is normalized and all of the listed symptoms are eliminated.
Reviews from doctors
Experts characterize the drug as a highly effective and universal hormonal remedy for various pathologies of the female reproductive system. They recommend this medicine to many patients who have similar problems, however, to achieve the best result, according to doctors, it is necessary to correctly determine the exact dosage and days of the cycle on which to start taking the medicine. If such requirements are not met, the effectiveness of the medicine will be low, moreover, it may cause some complications, for example, the development of bleeding.
How long to take the drug
The medicine is taken until any threat of pregnancy has passed. In most cases, the drug is discontinued after the sixteenth week of pregnancy, as mentioned above. But for some mothers, the threat of miscarriage remains, and they are forced to continue the course of treatment until the twentieth week.
The drug is not discontinued abruptly, because this can harm the fetus. If the dosage was high, then it is reduced by 10 mg per week. In this case, there should be no threat of interruption of pregnancy again. If everything is normal, then the drug is discontinued completely (from 10 mg to 0 mg).
